Polynucleotides and Exosomes EXPOSED: The Truth Behind the Hype

Not all injectables are created equal. If you’ve been researching skin boosters lately, you’ve likely come across two words:

Polynucleotides and Exosomes

They’re both trending.

They both claim to rejuvenate the skin from within. But they work in very different ways, and which one you choose should depend on what your skin actually needs to recover from.

Here’s a breakdown that cuts through the buzzwords.

Polynucleotides: The Repair First, Glow Later Treatment

Polynucleotides are like the emergency response team for damaged skin.

They’re derived from highly purified salmon DNA and work by triggering tissue repair, encouraging fibroblast activity, and deeply hydrating the skin from within.

Best for:

• Skin that’s inflamed, sensitive, or struggling post-treatment

• Acne scarring, rosacea, or sun damage

• Strengthening the skin barrier before more aggressive procedures

Key benefits:

• Boosts skin regeneration

• Reduces inflammation

• Improves skin density and elasticity over time

This isn’t your quick-fix glow. It’s a medical-grade repair treatment with cumulative benefits, and a favourite for clients who want long-term strengthening, not just surface-level hydration.

See our Polynucleotide treatments

Exosomes: The Power Serum That Thinks It’s Stem Cells

Exosomes are tiny extracellular vesicles derived from stem cells, and they’re rapidly becoming a buzzword in regenerative aesthetics. Think of them as cell messengers that tell your skin to behave younger.

Best for:

• Accelerating post-procedure recovery

• Ageing skin that needs lifting, firming, or brightness

• Enhancing results from microneedling, RF, or resurfacing treatments

Key benefits:

• Stimulates collagen and elastin

• Speeds up healing

• Evens tone and brightens dull or uneven skin

Exosomes are often applied topically after treatments like RF microneedling or lasers, but new injectable versions are emerging, and they’re potent.

See our Exosome treatments

So, Polynucleotides and Exosomes: Which One Should You Choose? Polynucleotides + Exosomes

Both are exceptional. But they’re not interchangeable.

	Polynucleotides	Exosomes
Primary Purpose	Repair and rebuild	Regenerate and rejuvenate
Best For	Damaged, sensitive, post-inflammatory skin	Dull, ageing, or post-treatment skin
Speed of Results	Gradual, strengthening over time	Faster, especially when paired with tech
Pair With	Prepping skin before peels, injectables	Post-RF, microneedling, lasers

Our Clinical Take.

At You. we often use Polynucleotides as your skin’s foundation phase, to stabilise, calm, and rebuild. Once the skin is stronger and calmer, Exosomes can supercharge the next level of transformation.

It’s not about which is better. It’s about what your skin needs right now.

Want to know if Polynucleotides and Exosomes are right for you?

Book a consultation and we’ll map out a treatment plan that aligns with your skin goals, your concerns, and the real science of what works.

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